FITC标记的可溶性E选择素抗体
产品名称： FITC标记的可溶性E选择素抗体
英文名称： Anti-E-selectin/FITC
产品编号： HZ-7358R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-E-selectin/FITC Conjugated antibody
FITC标记的可溶性E选择素抗体
| 英文名称 | Anti-E-selectin/FITC |
| 中文名称 | FITC标记的可溶性E选择素抗体 |
| 别 名 | Endothelial leukocyte adhesion molecule 1; ELAM-1; Leukocyte-endothelial cell adhesion molecule 2; LECAM2; CD62 antigen-like family member E; CD62E antigen; LYAM2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 细胞粘附分子 细胞表面分子 细胞类型标志物 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 65kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human E-selectin |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The se-selectin is expressed by cytokine-stimulated endothelial cells. It is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. This gene is present in single copy in the human genome and contains 14 exons spanning about 13 kb of DNA. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. Subunit: Interacts with PSGL1/SELPLG through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction. Subcellular Location: Membrane; Single-pass type I membrane protein. Similarity: Belongs to the selectin/LECAM family. Contains 1 C-type lectin domain. Contains 1 EGF-like domain. Contains 6 Sushi (CCP/SCR) domains. Database links: Entrez Gene: 6401 Human Entrez Gene: 20339 Mouse Entrez Gene: 25544 Rat Omim: 131210 Human SwissProt: P16581 Human SwissProt: Q00690 Mouse SwissProt: P98105 Rat Unigene: 82848 Human Unigene: 5245 Mouse Unigene: 10359 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SE选择素是由细胞因子刺激的内皮细胞表达的。据认为，它通过介导细胞与血管内膜的粘附而导致炎症部位白细胞的积累。它具有结构特征，如存在凝集素和EGF样结构域，随后是包含6个保守半胱氨酸残基的短共识重复（SCR）结构域。这些蛋白质是selectin家族细胞粘附分子的一部分。该基因存在于人类基因组中的单一拷贝中，包含14个外显子，约13 kb的DNA。粘附分子参与白细胞与内皮细胞的相互作用，似乎与动脉粥样硬化的发病机制有关。