FITC标记的有丝分裂蛋白BUB3抗体
产品名称： FITC标记的有丝分裂蛋白BUB3抗体
英文名称： Anti-Bub3/FITC
产品编号： HZ-7835R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Bub3/FITC Conjugated antibody
FITC标记的有丝分裂蛋白BUB3抗体
| 英文名称 | Anti-Bub3/FITC |
| 中文名称 | FITC标记的有丝分裂蛋白BUB3抗体 |
| 别 名 | BUB 3; BUB 3L; BUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog; bub3; BUB3 budding uninhibited by benzimidazoles 3 homolog; BUB3_HUMAN; BUB3L; Budding uninhibited by benomyl; Budding uninhibited by benzimidazoles 3; Budding uninhibited by benzimidazoles 3 homolog (S. cerevisiae); Budding uninhibited by benzimidazoles 3 homolog (yeast); Budding uninhibited by benzimidazoles 3 homolog; Budding uninhibited by benzimidazoles 3, S. cerevisiae, homolog of antibody C78067; hBUB3; Mitotic checkpoint component; Mitotic checkpoint protein bub3; WD repeat type I transmembrane protein A72.5; Aa2-050; AU019800; AU021329; AU043350; AW146323. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 细胞周期蛋白 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 36kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Bub3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Function: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Subunit: Interacts with BUB1 and BUBR1. The BUB1/BUB3 complex interacts with MAD1L1. Subcellular Location: Nucleus. Chromosome, centromere, kinetochore (By similarity). Post-translational modifications: Poly-ADP-ribosylated by PARP1 (By similarity). Similarity: Belongs to the WD repeat BUB3 family. Contains 5 WD repeats. Database links: Entrez Gene: 539594 Cow Entrez Gene: 9184 Human Entrez Gene: 12237 Mouse Entrez Gene: 100172494 Orangutan Entrez Gene: 361662 Rat Omim: 603719 Human SwissProt: Q1JQB2 Cow SwissProt: O43684 Human SwissProt: Q9WVA3 Mouse SwissProt: Q5RB58 Orangutan Unigene: 418533 Human Unigene: 441749 Mouse Unigene: 927 Mouse Unigene: 6897 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
在纺锤体装配检查点信号和促进正确的着丝粒微管（K-MT）附件的建立中具有双重功能。促进双极附着体稳定端的形成。BUB1的着丝粒定位是必需的。调节卵母细胞减数分裂过程中染色体的分离。BUB1/BUB3复合物在激活纺锤体装配点时抑制后期促进复合物或环细胞体（APC/C）的作用，并通过磷酸化其激活剂CDC20抑制APC/C的泛素连接酶活性。这种复合物也可以磷酸化MAD1L1。