Product Information
    
 
    

    

        

            

                

                
Product Name
                
                

                
Cat#
                
                

                
Size
                
                

                
Price（¥）
                
            
            

                

                
Recombinant Rat Glial Cell Line-derived Neurotrophic Factor
                
(Rat GDNF)
                
                

                
92104ES10
                
                

                
10 μg
                
                

                
1855.00
                
            
            

                

                
92104ES60
                
                

                
100 μg
                
                

                
13615.00
                
            
            

                

                
92104ES76
                
                

                
500 μg
                
                

                
35395.00
                
            
        
    
    
    
 
    
Product Description
    
 
    
Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-β superfamily. It is a founding member of the GDNF family of ligands (GFL) and has been shown to interact with GFRA2 and GDNF family receptor alpha. Mature rat and human GDNF exhibit approximately 93% amino acid sequence identity and show considerable species cross-reactivity. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. In embryonic midbrain cultures, recombinant human GDNF promoted the survival and morphological differentiation of dopaminergic neurons and increased their high-affinity dopamine uptake.
    
 
    
Product Properties
    
 
    

    

        

            

                

                
Synonyms
                
                

                
Astrocyte-derived trophic factor, ATF, ATF-1, ATF2, GDNF, HFB1-GDNF, HGDNF, HSCR3
                
            
            

                

                
Accession
                
                

                
Q07731
                
            
            

                

                
GeneID
                
                

                
25453
                
            
            

                

                
Source
                
                

                
E.coli-derived rat GDNF, Ser78-Ile211.
                
            
            

                

                
Molecular Weight
                
                

                
Approximately 29.8 kDa.
                
            
            

                

                
AA Sequence
                
                

                
SPDKQAAALP RRERNRQAAA ASPENSRGKG RRGQRGKNRG CVLTAIHLNV TDLGLGYETK EELIFRYCSG SCEAAETMYD KILKNLSRSR RLTSDKVGQA CCRPVAFDDD LSFLDDSLVY HILRKHSAKR CGCI
                
            
            

                

                
Tag
                
                

                
None
                
            
            

                

                
Physical Appearance
                
                

                
Sterile Filtered White lyophilized (freeze-dried) powder.
                
            
            

                
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